Systemic destruction

Systemic destruction

Cristae in crisis ristae, the complex involutions of the mitochondrial inner membrane, vastly increase the surface area across which ATP synthase can generate a proton gradient. Now, new findings from Jean Velours (Université Victor Ségalen, Bordeaux, France) and colleagues suggest that ATP synthase may be important in forming cristae in the first place. Velours' theory is that oligomerization ...

On Systemic Destruction of Human Locomotor System

Locomotor system disorders affect a vast majority of people at some time in their life bringing pain, functional limitations, social and economic implications. Modern medicine cannot offer prevention and effective treatment for most chronic musculoskeletal conditions, because their etiology and pathogenesis are unknown. This is due to the lack of systemic understanding of the locomotor system f...

Modulated electro-hyperthermia induced loco-regional and systemic tumor destruction in colorectal cancer allografts

Background: Modulated electro-hyperthermia (mEHT), a non-invasive intervention using 13.56 MHz radiofrequency, can selectively target cancers due to their elevated glycolysis (Warburg-effect), extracellular ion concentration and conductivity compared to normal tissues. We showed earlier that mEHT alone can provoke apoptosis and damage associated molecular pattern (DAMP) signals in human HT29 co...

Autoregulation of the total systemic circulation following destruction of the central nervous system in the dog.

Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system

BACKGROUND Cancer treatment with a variety of chemotherapeutic agents often is associated with delayed adverse neurological consequences. Despite their clinical importance, almost nothing is known about the basis for such effects. It is not even known whether the occurrence of delayed adverse effects requires exposure to multiple chemotherapeutic agents, the presence of both chemotherapeutic ag...